Publications and output


For updated citations please see Citations@google scholar

Published Articles

39. Heparin-derived theranostic nanoprobes overcome the blood-brain barrier and target glioma in murine model
S. Samanta,V. Le Joncour, O. Wegrzyniak, V. Rangasami, H. Ali-Loytty, T. Hong, R. K. Selvaraju, O. Aberg, J. Hilborn, P. Laakkonen, O. P. Varghese, O. Eriksson, H. Cabral, O. P. Oommen,* Advanced Therapeutics, 2022,DOI: 10.1002/adtp.202200001 (Link)

38. Interpenetrating Gallol Functionalized Tissue Adhesive Hyaluronic Acid Hydrogel Polarizes Macrophages to an Immunosuppressive Phenotype
S. Samanta, V. K. Rangasami, H. Sarlus, J. R.K. Samal, A. D. Evans, V. S. Parihar, O. P. Varghese, R. A. Harris, and O. P. Oommen,* Acta Biomaterialia, 2022, 142, 36-48 (Link)

37. Bidirectional cell-matrix interaction dictates neuronal network formation in a brain mimetic 3D scaffold
S. Samanta, L. Ylä-Outinen, V. K. Rangasami, S. Narkilahti and O. P. Oommen,* Acta Biomaterialia, 2022, 140, 314-323 (Link)

36. Hyaluronic Acid-Functionalized Nanomicelles Enhance SAHA Efficacy in 3D Endometrial Cancer Models
K. Edwards, S. Yao, S. Pisano, V. Feltracco, K. Brusehafer, S. Samanta, O. P Oommen, S. A. Gazze, R. Paravati, H. Maddison, C. Li, D. Gonzalez, R. S. Conlan, L. Francis, Cancers, 2021, 13 (16), 4032 (Link)

35. Streptococcus pneumoniae pneumolysin and neuraminidase A convert high-density lipoproteins into pro-atherogenic particles
S. Syed, E. Nissilä, H. Ruhanen, S. Fudo, M. O. Gaytán, S. P. Sihvo, M. B. Lorey, J. Metso, K. Öörni, S. J. King, O. P. Oommen, M. Jauhiainen, S. Meri, R. Käkelä, K. Haapasalo, iScience, 2021, 24 (6), 102535 (Link)

34. Facile delivery of functional siRNA mediated by redox responsive pluronic micelle: A modular nano-assembly for targeted delivery
S. Kadekar, G. N. Nawale, V. K. Rangasami, V. L. Joncour, P. Laakkonen, J. Hilborn, O. P. Varghese and O. P. Oommen,* Biomaterial Sciences, 2021, 9 (11), 3939-3944 (Link)

33. Pluronic Micelle-Mediated Tissue Factor Silencing Enhances Hemocompatibility, Stemness, Differentiation Potential, and Paracrine Signaling of Mesenchymal Stem Cells
V. K. Rangasami, G. Nawale, K. Asawa, S. Kadekar, S. Samanta, B. Nilsson, K. N Ekdahl, S. Miettinen, J. Hilborn, Y. Teramura, O. P. Varghese, and O. P. Oommen,* Biomacromolecules, 2021, 22, 5, 1980-1989 (Link)

32. An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels
S. Samanta, V. K. Rangasami, N. A. Murugan, O. P. Varghese, O. P. Oommen,* Polymer Chemistry, 2021, 12, 2987-2991 (Link)

31. Discrepancies on the role of oxygen gradient and culture condition on mesenchymal stem cell fate
J. R. K. Samal, V. K. Rangasami, S. Samanta, O. P. Varghese, and O. P. Oommen,* Advanced Healthcare Materials, 2021, 10, 2002058 DOI: 10.1002/adhm.202002058 (Link)

30. Harnessing hyaluronic acid-based nanoparticles for combination therapy: A novel approach for suppressing systemic inflammation and to promote antitumor macrophage polarization
V. K. Rangasami, S. Samanta, V. S. Parihar, K. Asawa, K. Zhu, O. P. Varghese, Y. Teramura, B. Nilsson, J. Hilborn, R. A. Harris and O. P. Oommen,* Carbohydrate Polymers, 2021, 117291 (Link)

29. ILC1 drive intestinal epithelial and matrix remodelling
G. M. Jowett, M. D. A. Norman, T. T. L. Yu, P. Rosell Arévalo, D. Hoogland, S. T. Lust, E. Read, E. Hamrud, N. J. Walters, U. Niazi, M. W. H. Chung, D. Marciano, O. S. Omer, T. Zabinski, D. Danovi, G. M. Lord, J. Hilborn, N. D. Evans, C. A. Dreiss, L. Bozec, O. P. Oommen, C. D. Lorenz, R. M. P. da Silva, J. F. Neves, E. Gentleman, Nature Materials, 2020 (Link)

28. Hyaluronan derived nanoparticle for simvastatin delivery: Evaluation of simvastatin induced myotoxicity in tissue engineered skeletal muscle
J. M. Jones, D. J. Player, V. K. Rangasami, S. Samanta, J. Hilborn, M. P. Lewis, O. P. Oommen,* V. Mudera, Biomaterial Sciences, 2020 8, 302-312 (Link)

27. First Aldol Cross-linked Hyaluronic Acid Hydrogel: Fast and Hydrolytically Stable Hydrogel with Tissue Adhesive Properties
D. Bermejo-Velasco, S. Kadekar, M. V. T. da Costa, O. P. Oommen, K. Gamstedt, J. Hilborn, O. P. Varghese, ACS Applied Materials and Interface, 2019 11, 38232−38239 (Link)

26.Tissue Adhesive Hyaluronic Acid Hydrogels for Sutureless Stem Cell Delivery and Regeneration of Corneal Epithelium and Stroma
L. Koivusalo, M. Kauppila, T. Ilmarinen, S. Samanta, V. S. Parihar, S. Miettinen, O. P. Oommen,* H. Skottman,* Biomaterials, 2019, 225, 119516 (Link)

25. Influence of ions to modulate hydrazone and oxime reaction kinetics to obtain dynamically cross-linked hyaluronic acid hydrogels
S. Wang, G. N. Nawale, O. P. Oommen, J. Hilborn, O. P. Varghese, Polym. Chem., 2019 10, 4322-4327 (Link)

24. Carbon nanotube doped pericardial matrix derived electroconductive biohybrid hydrogel for cardiac tissue engineering
K. Roshanbinfar, Z. Mohammadi, A. S-M Mesgar, M. M. Dehghan, O. P. Oommen, J. Hilborn, F. B. Engel, Biomaterial Sciences, 2019, 7, 3906 (Link)

23. Synthetic design of asymmetric miRNA with engineered 3′-overhang to improve strand selection
S. Kadekar, G. N. Nawale, K. Karlsson, C. Ålander, O. P. Oommen, O. P. Varghese, Mol. Ther. Nucleic Acids, 2019, 16, 597-604 , (Link)

22. Modulating thiol pKa promotes disulfide formation at physiological pH: An elegant strategy to design disulfide crosslinked hyaluronic acid hydrogels
D. Bermejo-Velasco, A. Azemar, O. P. Oommen, J. Hilborn, O. P Varghese Biomacromolecules, 2019, 20, 1412–1420 (Link)

21. Unexpected role of hyaluronic acid in trafficking siRNA across cellular barrier: First biomimetic, anionic, non-viral transfection method
M. Paidikondala, V. K. Rangasami, G. N. Nawale, T. Casalini, G. Perale, S. Kadekar, G. Mohanty, T. Salminen, O. P. Oommen,* O. P. Varghese,* Angew. Chem. Int. Edn., 2019, 58, 2815-2819 (Link)

20. Surface-modified hyaluronan hydrogels for regeneration of corneal epithelium and stroma
L. Koivusalo, T. Ilmarinen, S. Miettinen, H. Skottman, O. P. Oommen Investigative Ophthalmology & Visual Science, 2018, 59 (9), 2281 (Link)

19. Bi-directional cell-pericellular matrix interactions direct stem cell fate
S. A. Ferreira, M. S. Motwani, P. A. Faull, A. J. Seymour, T. T. L. Yu, M. Enayati, D. K. Taheem, E. M. Kania, O. P. Oommen, T. Ahmed, S. Loaiza, K. Parzych, F. Dazzi, H. W. Auner, O. P. Varghese, F. Festy, A. E. Grigoriadis, A. P. Snijders, L. Bozec, E. Gentleman, Nature Communications, 2018, 9, 4049 (Link)

18. Thiazolidine chemistry revisited: A fast, efficient and stable click type reaction at physiological pH
D. Bermejo-Velasco, G. N. Nawale, O. P. Oommen, J. Hilborn, O. P. Varghese Chemical Communications, 2018, 54 (88), 12507-12510 (Link)

17. Saline Accelerates Oxime Reaction with Aldehyde and Keto Substrates at Physiological pH
S. Wang, G. N. Navale, S. Kadekar, O. P. Oommen, N. K. Jena, S. Chakraborty, J. Hilborn, O. P. Varghese, Scientific Reports, 2018, 8, 2193 (Link)

16. Synthetic Design of Growth Factor Sequestering Extracellular Matrix Mimetic Hydrogel for Promoting In Vivo Bone Formation
H. Yan, T. Casalini, G. Hulsart-Billström, S. Wang, O. P. Oommen, M. Salvalaglio, S. Larsson, J. Hilborn, O. P. Varghese, Biomaterials, 2018, 161, 190-202 (Link)

15. Gold Nanoparticles Approach to Detect Chondroitin Sulphate and Hyaluronic Acid Urothelial Coating
G. Guelfi, V. Stefanetti, D. Zampini, O. P. Oommen, G. Brecchia, C. Dall'Aglio, R. Arcelli, G. Cochetti, A. Boni, E. Mearini, Scientific Reports, 2017, 7, 10355 (Link)

14. Injectable and Thermoresponsive Pericardial Matrix Derived Conductive Scaffold for Cardiac Applications
K. Roshanbinfar, J. Hilborn, O. P. Varghese, O. P. Oommen,* RSC Advances, 2017, 7, 31980-31988 (Link)

13. Chondroitin Sulfate Coated Gold Nanoparticles: A New Strategy to Resolve Multidrug Resistance and Thromboinflammation
D. Gurav, O. P. Varghese, O. A. Hamad, B. Nilsson, J. Hilborn, O. P. Oommen,* Chemical Communications,  2016, 52, 966-969 (Link)

12. Multifunctional Hyaluronic Acid and Chondroitin Sulfate Nanoparticles: Impact of Glycosaminoglycan Presentation on Receptor Mediated Cellular Uptake and Immune Activation
O. P. Oommen,* C. Duehrkop, B. Nilsson, J. Hilborn and O. P. Varghese, ACS Applied Materials and Interface, 2016, 8, 20614–20624 (Link)

11. Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery
O. P. Varghese, J. Liu, K. Sundaram, J. Hilborn, O. P. Oommen,* Biomaterials Sciences, 2016, 4, 1310-1313, (Link)

10. Synthesis and Anticancer Properties of Fucoidan-Mimetic Glycopolymer Coated Gold Nanoparticles
M. Tengdelius, D. Gurav, P. Konradsson,P. Påhlsson, M. Griffith, O. P. Oommen,* Chemical Communications 2015, 51, 8532-8535 (Link)

9. Chondroitin Sulfate-Coated DNA-Nanoplexes Enhance Transfection Efficiency by Controlling Plasmid Release from Endosomes: A New Insight into Modulating Nonviral Gene Transfection
H. Yan, O. P. Oommen, D. Yu, J. Hilborn, H. Qian, O. P. Varghese, Advanced Functional Materials, 2015, 25, 3907–3915. (Link)

8. Insights into the Mechanism and Catalysis of Oxime Coupling Chemistry at Physiological pH
S. Wang, D. Gurav, O. P. Oommen,* O. P. Varghese,* Chemistry – A European Journal, 2015, 21, 5980-5985 (Link)

7. Synthesis and energetic properties of high-nitrogen substituted bishomocubanes
S. Lal, L. Mallick, S. Rajkumar, O. P. Oommen, S. Reshmi, N. Kumbhakarna, A. Chowdhury, I. N. N. Namboothiri, Journal of Material Chemistry - A, 2015, 3, 22118-22128 (Link)

6. 2'-N-Guanidino, 4'-C-Ethylene Bridged Thymidine (GENA-T) modified Oligonucleotide Exhibits Triplex Formation with Excellent Enzymatic Stability
J. Barman, D. Gurav, O. P. Oommen, O. P. Varghese, RSC Advance, 2015, 5, 12257-12260 (Link)

5. Tailored Doxorubicin-Hyaluronan Conjugate as a Potent Anticancer Glyco-Drug: An Alternative to Prodrug Approach
O. P. Oommen,* M. Sloff, J. Garousi, and O. P. Varghese, Macromolecular Bioscience,  2014, 14, 327-333. (Link)

4. Smart design of stable extracellular matrix mimetic hydrogel: synthesis, characterization, in vitro and in vivo evaluation for tissue engineering
O. P. Oommen, S. Wang, M. Kisiel, M. Sloff, J. Hilborn and O. P. Varghese, Advanced Functional Materials, 2013, 23, 1273–1280. Special highlight in

3. Mild and efficient strategy for site-selective aldehyde modification of glycosaminoglycans: tailoring hydrogels with tunable release of growth factor
S. Wang, O. P. Oommen, H. Yan and O. P. Varghese, Biomacromolecules, 2013, 14, 2427–2432. (Link)

2. Microencapsulation of cells, including islets, within stable ultra-thin membranes of maleimide-conjugated PEG-lipid with multifunctional crosslinkers
Y Teramura, O. P. Oommen, J. Olerud, J. Hilborn, B Nilsson, Biomaterials2013, 34, 2683-2693. (Link)

1. Critical assessment of rhBMP-2 mediated bone induction: an in vitro and in vivo evaluation
M. Kisiel, M. Ventura, O. P. Oommen, A. George, X. F. Walboomers, J. Hilborn and O. P. Varghese, Journal of Controlled Release2012, 162, 646-653. (Link)


Sept. 2016- Chondroitin Sulfate derived nanoparticles: Overcoming challenges of cancer nanomedicine. 2nd International Conference on ‘Immune Responses to Biosurfaces’ Rhodes, Greece (Keynote lecture)

June 2016- Pericardial matrix derived hydrogels functionalized with multiwalled carbon nanotubes for cardiac applications. TERMIS EU Chapter, Uppsala, Sweden (Keynote lecture).

June 2016- Improving safety and efficacy of cancer drugs: Biopolymer based drug delivery. TERMIS EU Chapter, Uppsala, Sweden (Keynote lecture).

Oct. 2014- Biopolymer mediated delivery of chemotherapeutic agents for cancer specific cytotoxicity without inducing haemotoxicity. 1st International Conference on ‘Immune Responses to Biosurfaces’ Chania, Greece (Invited lecture)

• Sept. 2014- Influence of Nanoparticle Formulation on Instant Blood-mediated Inflammatory Response. “Bridging the Translational Gap – Stem Cells and Biomaterials for Regenerative Medicine.” Linköping University, Sweden (Invited lecture).


‘Improved small interfering ribonucleic acid molecules’, O. P. Varghese and O. P. Oommen, (2015) International patent application, PCT/EP2015/056012, US Patent Application No. 15/127616.

Nucleic acid molecules with enhanced activity’ O. P. Varghese and O. P. Oommen, (2016) International patent application, PCT/EP2016/072466. This patents applies for microRNA technology.

‘Functionalized Bis-homocubyl Systems as Novel Ligands and Catalysts in Asymmetric Reactions’, I. N. N. Namboothiri, O. P. Oommen, S. Rajkumar and N. Ayyagari, Indian Patent Application 2014, 262807.


I am the co-founder and partner of Uppsala Therapeutics AB (


‘Synthetic design of hyaluronan derivatives for therapeutic applications’. O. P. Oommen, S. Wang, J. Hilborn, O. P. Varghese, Smithers Rapra Publishers, United Kingdom, 2014, Page 149-176 from the book entitled ‘Hyaluronic Acid for Biomedical and Pharmaceutical Applications’.